3AUV

Predicting Amino Acid Preferences in the Complementarity Determining Regions of an Antibody-Antigen Recognition Interface

3AUV の概要

• エントリーDOI: 10.2210/pdb3auv/pdb
• 分子名称: sc-dsFv derived from the G6-Fab (2 entities in total)
• 機能のキーワード: sc-dsfv (disulfide-stabilized scfv), scfv, monovalent antibody, vegf, antibody engineering, immune system
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 174938.09

構造登録者

Yu, C.M.,Peng, H.P.,Chen, I.C.,Lee, Y.C.,Chen, J.B.,Tsai, K.C.,Chen, C.T.,Chang, J.Y.,Yang, E.W.,Hsu, P.C.,Jian, J.W.,Hsu, H.J.,Chang, H.J.,Hsu, W.L.,Huang, K.F.,Ma, A.C.,Yang, A.S. (登録日: 2011-02-16, 公開日: 2012-02-22, 最終更新日: 2012-04-25)

• 主引用文献: Yu, C.M.,Peng, H.P.,Chen, I.C.,Lee, Y.C.,Chen, J.B.,Tsai, K.C.,Chen, C.T.,Chang, J.Y.,Yang, E.W.,Hsu, P.C.,Jian, J.W.,Hsu, H.J.,Chang, H.J.,Hsu, W.L.,Huang, K.F.,Ma, A.C.,Yang, A.S.; Rationalization and design of the complementarity determining region sequences in an antibody-antigen recognition interface; Plos One, 7:e33340-e33340, 2012; PubMed: 22457753; DOI: 10.1371/journal.pone.0033340

実験手法

X-RAY DIFFRACTION (2.4 Å)