3AO4

Fragment-based approach to the design of ligands targeting a novel site on HIV-1 integrase

3AO4 の概要

• エントリーDOI: 10.2210/pdb3ao4/pdb
• 関連するPDBエントリー: 1bl3 3AO1 3AO2 3AO3 3AO5 3L3U 3OVN
• 分子名称: POL polyprotein, CADMIUM ION, CHLORIDE ION, ... (6 entities in total)
• 機能のキーワード: dna integration, aids, integrase, endonuclease, polynucleotidyl transferase, dna binding, viral protein, rnaseh, fragment binding, viral protein-transferase inhibitor complex, viral protein/transferase inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 36783.46

構造登録者

Wielens, J.,Headey, S.J.,Parker, M.W.,Chalmers, D.K.,Scanlon, M.J. (登録日: 2010-09-20, 公開日: 2011-03-09, 最終更新日: 2023-11-01)

• 主引用文献: Wielens, J.,Headey, S.J.,Deadman, J.J.,Rhodes, D.I.,Parker, M.W.,Chalmers, D.K.,Scanlon, M.J.; Fragment-based design of ligands targeting a novel site on the integrase enzyme of human immunodeficiency virus 1; Chemmedchem, 6:258-261, 2011; PubMed: 21275048; DOI: 10.1002/cmdc.201000483

実験手法

X-RAY DIFFRACTION (1.95 Å)