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3AN4

Human PPAR gamma ligand binding domain in complex with a gamma selective agonist MO4R

Summary for 3AN4
Entry DOI10.2210/pdb3an4/pdb
Related3AN3
DescriptorPeroxisome proliferator-activated receptor gamma, (2R)-2-benzyl-3-(4-propoxy-3-{[({4-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-yl]phenyl}carbonyl)amino]methyl}phenyl)propanoic acid (3 entities in total)
Functional Keywordsmainly alpha, nuclear receptor, transcription
Biological sourceHomo sapiens (human)
Cellular locationNucleus: P37231
Total number of polymer chains2
Total formula weight65627.05
Authors
Oyama, T.,Ohashi, M.,Waku, T.,Miyachi, H.,Morikawa, K. (deposition date: 2010-08-30, release date: 2011-07-27, Last modification date: 2023-11-01)
Primary citationOhashi, M.,Oyama, T.,Nakagome, I.,Satoh, M.,Nishio, Y.,Nobusada, H.,Hirono, S.,Morikawa, K.,Hashimoto, Y.,Miyachi, H.
Design, Synthesis, and Structural Analysis of Phenylpropanoic Acid-Type PPAR gamma-Selective Agonists: Discovery of Reversed Stereochemistry-Activity Relationship
J.Med.Chem., 54:331-341, 2011
Cited by
PubMed: 21128600
DOI: 10.1021/jm101233f
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

217705

건을2024-03-27부터공개중

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