3ALZ

Crystal structure of the measles virus hemagglutinin bound to its cellular receptor SLAM (Form I)

3ALZ の概要

• エントリーDOI: 10.2210/pdb3alz/pdb
• 関連するPDBエントリー: 3ALW 3ALX
• 分子名称: Hemagglutinin, CDw150, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• 機能のキーワード: viral protein-receptor complex, six-bladed beta-propeller fold, immunoglobulin fold, beta-sandwich, viral protein-membrane protein complex, viral protein/membrane protein
• 由来する生物種: Measles virus; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 71112.01

構造登録者

Hashiguchi, T.,Ose, T.,Kubota, M.,Maita, N.,Kamishikiryo, J.,Maenaka, K.,Yanagi, Y. (登録日: 2010-08-11, 公開日: 2011-01-12, 最終更新日: 2024-10-23)

主引用文献

Hashiguchi, T.,Ose, T.,Kubota, M.,Maita, N.,Kamishikiryo, J.,Maenaka, K.,Yanagi, Y.
Structure of the measles virus hemagglutinin bound to its cellular receptor SLAM
Nat.Struct.Mol.Biol., 18:135-141, 2011

PubMed Abstract: Measles virus, a major cause of childhood morbidity and mortality worldwide, predominantly infects immune cells using signaling lymphocyte activation molecule (SLAM) as a cellular receptor. Here we present crystal structures of measles virus hemagglutinin (MV-H), the receptor-binding glycoprotein, in complex with SLAM. The MV-H head domain binds to a β-sheet of the membrane-distal ectodomain of SLAM using the side of its β-propeller fold. This is distinct from attachment proteins of other paramyxoviruses that bind receptors using the top of their β-propeller. The structure provides templates for antiviral drug design, an explanation for the effectiveness of the measles virus vaccine, and a model of the homophilic SLAM-SLAM interaction involved in immune modulations. Notably, the crystal structures obtained show two forms of the MV-H-SLAM tetrameric assembly (dimer of dimers), which may have implications for the mechanism of fusion triggering.

PubMed: 21217702
DOI: 10.1038/nsmb.1969

実験手法

X-RAY DIFFRACTION (4.515 Å)