3AI8

Cathepsin B in complex with the nitroxoline

Summary for 3AI8

Entry DOI	10.2210/pdb3ai8/pdb
Descriptor	Cathepsin B, 5-nitroquinolin-8-ol (3 entities in total)
Functional Keywords	cathepsin b, reversible inhibitor, nitroxoline, 8-hydroxy-5-nitroquinoline, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Lysosome: P07858
Total number of polymer chains	2
Total formula weight	56550.94
Authors	Renko, M.,Mirkovic, B.,Gobec, S.,Kos, J.,Turk, D. (deposition date: 2010-05-11, release date: 2011-05-18, Last modification date: 2024-10-23)
Primary citation	Mirkovic, B.,Renko, M.,Turk, S.,Sosic, I.,Jevnikar, Z.,Obermajer, N.,Turk, D.,Gobec, S.,Kos, J. Novel mechanism of cathepsin B inhibition by antibiotic nitroxoline and related compounds Chemmedchem, 6:1351-1356, 2011 Cited by PubMed: 21598397 DOI: 10.1002/cmdc.201100098 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.11 Å)

Structure validation