3AC3

Crystal structure of pyrazolo pyrimidine derivative bound to the kinase domain of human LCK, (auto-phosphorylated on TYR394)

3AC3 の概要

• エントリーDOI: 10.2210/pdb3ac3/pdb
• 関連するPDBエントリー: 3AC1 3AC2 3AC4 3AC5 3AC8 3ACJ 3ACK 3LCK
• 分子名称: Proto-oncogene tyrosine-protein kinase LCK, SULFATE ION, 2-[(3,5-dimethoxyphenyl)amino]-5-ethyl-7-[(2R)-2-(hydroxymethyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, ... (4 entities in total)
• 機能のキーワード: tyrosine-protein kinase, atp-binding, phosphorylation, signal transduction, alternative splicing, kinase, sh2 domain, sh3 domain, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : P06239
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33698.22

構造登録者

Tsuji, E. (登録日: 2009-12-28, 公開日: 2010-06-30, 最終更新日: 2023-11-15)

• 主引用文献: Ozawa, M.,Ozawa, T.,Tsuji, E.,Okazaki, K.,Takeda, K.; Ab initio fragment molecular orbital study of ligand binding to leukocyte-specific protein tyrosine (LCK) kinase; To be Published,

実験手法

X-RAY DIFFRACTION (2.55 Å)