3A7E

Crystal structure of human COMT complexed with SAM and 3,5-dinitrocatechol

3A7E の概要

• エントリーDOI: 10.2210/pdb3a7e/pdb
• 関連するPDBエントリー: 1VID 3A7D 3BWM 3BWY
• 分子名称: Catechol O-methyltransferase, MAGNESIUM ION, S-ADENOSYLMETHIONINE, ... (5 entities in total)
• 機能のキーワード: comt, alternative initiation, catecholamine metabolism, magnesium, methyltransferase, neurotransmitter degradation, s-adenosyl-l-methionine, transferase, cell membrane, membrane, metal-binding, phosphoprotein, signal-anchor, transmembrane
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Isoform Soluble: Cytoplasm. Isoform Membrane-bound: Cell membrane; Single-pass type II membrane protein; Extracellular side : P21964
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24649.45

構造登録者

Tsuji, E. (登録日: 2009-09-26, 公開日: 2010-09-15, 最終更新日: 2023-11-01)

• 主引用文献: Nonaka, Y.,Momose, T.,Ozawa, T.,Ozawa, M.,Nakatsu, M.,Tsuji, E.,Okazaki, K.,Takase, Y.,Kiyotani, T.; Hit to Lead: Comprehensive Strategy of de novo Scaffold Generation by FBDD. Part 1: In silico Fragments Linking and Verification of Spatial Proximity using Inter Ligand NOE Approachs; To be Published,

実験手法

X-RAY DIFFRACTION (2.8 Å)