3A61
Crystal structure of unphosphorylated p70S6K1 (Form II)
Summary for 3A61
Entry DOI | 10.2210/pdb3a61/pdb |
Related | 3A60 3A62 |
Descriptor | Ribosomal protein S6 kinase beta-1, STAUROSPORINE (2 entities in total) |
Functional Keywords | kinase, kinase domain, inactive, active, ribosomal s6 kinase, activation, alternative initiation, atp-binding, cell junction, cytoplasm, nucleotide-binding, phosphoprotein, polymorphism, serine/threonine-protein kinase, synapse, synaptosome, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cell junction, synapse, synaptosome . Isoform Alpha I: Nucleus. Isoform Alpha II: Cytoplasm: P23443 |
Total number of polymer chains | 1 |
Total formula weight | 37403.17 |
Authors | Sunami, T.,Byrne, N.,Diehl, R.E.,Funabashi, K.,Hall, D.L.,Ikuta, M.,Patel, S.B.,Shipman, J.M.,Smith, R.F.,Takahashi, I.,Zugay-Murphy, J.,Iwasawa, Y.,Lumb, K.J.,Munshi, S.K.,Sharma, S. (deposition date: 2009-08-18, release date: 2009-10-27, Last modification date: 2023-11-01) |
Primary citation | Sunami, T.,Byrne, N.,Diehl, R.E.,Funabashi, K.,Hall, D.L.,Ikuta, M.,Patel, S.B.,Shipman, J.M.,Smith, R.F.,Takahashi, I.,Zugay-Murphy, J.,Iwasawa, Y.,Lumb, K.J.,Munshi, S.K.,Sharma, S. Structural basis of human p70 ribosomal S6 kinase-1 regulation by activation loop phosphorylation. J.Biol.Chem., 285:4587-4594, 2010 Cited by PubMed: 19864428DOI: 10.1074/jbc.M109.040667 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.43 Å) |
Structure validation
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