3A61

Crystal structure of unphosphorylated p70S6K1 (Form II)

3A61 の概要

• エントリーDOI: 10.2210/pdb3a61/pdb
• 関連するPDBエントリー: 3A60 3A62
• 分子名称: Ribosomal protein S6 kinase beta-1, STAUROSPORINE (2 entities in total)
• 機能のキーワード: kinase, kinase domain, inactive, active, ribosomal s6 kinase, activation, alternative initiation, atp-binding, cell junction, cytoplasm, nucleotide-binding, phosphoprotein, polymorphism, serine/threonine-protein kinase, synapse, synaptosome, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell junction, synapse, synaptosome . Isoform Alpha I: Nucleus. Isoform Alpha II: Cytoplasm: P23443
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37403.17

構造登録者

Sunami, T.,Byrne, N.,Diehl, R.E.,Funabashi, K.,Hall, D.L.,Ikuta, M.,Patel, S.B.,Shipman, J.M.,Smith, R.F.,Takahashi, I.,Zugay-Murphy, J.,Iwasawa, Y.,Lumb, K.J.,Munshi, S.K.,Sharma, S. (登録日: 2009-08-18, 公開日: 2009-10-27, 最終更新日: 2023-11-01)

• 主引用文献: Sunami, T.,Byrne, N.,Diehl, R.E.,Funabashi, K.,Hall, D.L.,Ikuta, M.,Patel, S.B.,Shipman, J.M.,Smith, R.F.,Takahashi, I.,Zugay-Murphy, J.,Iwasawa, Y.,Lumb, K.J.,Munshi, S.K.,Sharma, S.; Structural basis of human p70 ribosomal S6 kinase-1 regulation by activation loop phosphorylation.; J.Biol.Chem., 285:4587-4594, 2010; PubMed: 19864428; DOI: 10.1074/jbc.M109.040667

実験手法

X-RAY DIFFRACTION (3.43 Å)