3EQM
Crystal structure of human placental aromatase cytochrome P450 in complex with androstenedione
Summary for 3EQM
Entry DOI | 10.2210/pdb3eqm/pdb |
Descriptor | Cytochrome P450 19A1, PROTOPORPHYRIN IX CONTAINING FE, 4-ANDROSTENE-3-17-DIONE, ... (5 entities in total) |
Functional Keywords | human aromatase, cytochrome p450, membrane protein, microsomal, estrogen, biosynthesis of steroid hormone, disease mutation, heme, iron, metal-binding, monooxygenase, oxidoreductase, phosphoprotein |
Biological source | Homo sapiens (Human) |
Cellular location | Membrane; Peripheral membrane protein: P11511 |
Total number of polymer chains | 1 |
Total formula weight | 59047.70 |
Authors | Ghosh, D. (deposition date: 2008-10-01, release date: 2008-12-23, Last modification date: 2024-02-21) |
Primary citation | Ghosh, D.,Griswold, J.,Erman, M.,Pangborn, W. Structural basis for androgen specificity and oestrogen synthesis in human aromatase. Nature, 457:219-223, 2009 Cited by PubMed: 19129847DOI: 10.1038/nature07614 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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