36UI

Crystal Structure of IDH2 (R140Q) in complex with covalent inhibitor LY3410738

これはPDB形式変換不可エントリーです。

36UI の概要

• エントリーDOI: 10.2210/pdb36ui/pdb
• 関連するPDBエントリー: 36TD
• 分子名称: Isocitrate dehydrogenase [NADP], mitochondrial, 7-{[(1S)-1-{4-[(1S)-2-cyclopropyl-1-(4-propanoylpiperazin-1-yl)ethyl]phenyl}ethyl]amino}-1-ethyl-1,4-dihydro-2H-pyrimido[4,5-d][1,3]oxazin-2-one, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
• 機能のキーワード: idh1, idh2, covalent, inhibitor, ly3410738, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 105749.17

構造登録者

Antonysamy, S.S. (登録日: 2026-07-01, 公開日: 2026-07-22)

• 主引用文献: Antonysamy, S.S.; LY3410738, a Covalent Inhibitor of Mutant IDH1/2, is Effective in Acute Myeloid Leukemia Preclinical Models; To Be Published,

実験手法

X-RAY DIFFRACTION (2.2 Å)