2ZM4

Crystal structure of imidazo quinoxaline 1 bound to the kinase domain of human LCK, activated form (auto-phosphorylated on TYR394)

2ZM4 の概要

• エントリーDOI: 10.2210/pdb2zm4/pdb
• 関連するPDBエントリー: 2ZM1 3LCK
• 分子名称: Proto-oncogene tyrosine-protein kinase LCK, SULFATE ION, DIMETHYL SULFOXIDE, ... (5 entities in total)
• 機能のキーワード: tyrosine-protein kinase, atp-binding, phosphorylation, signal transduction, alternative splicing, chromosomal rearrangement, cytoplasm, disease mutation, host-virus interaction, lipoprotein, membrane, myristate, nucleotide-binding, palmitate, phosphoprotein, proto-oncogene, sh2 domain, sh3 domain, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: P06239
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33742.77

構造登録者

Tsuji, E. (登録日: 2008-04-11, 公開日: 2008-10-14, 最終更新日: 2023-11-15)

• 主引用文献: Ozawa, T.,Tsuji, E.,Ozawa, M.,Handa, C.,Mukaiyama, H.,Nishimura, T.,Kobayashi, S.,Okazaki, K.; The importance of CH/pi hydrogen bonds in rational drug design: An ab initio fragment molecular orbital study to leukocyte-specific protein tyrosine (LCK) kinase; Bioorg.Med.Chem., 16:10311-10318, 2008; PubMed: 18977146; DOI: 10.1016/j.bmc.2008.10.041

実験手法

X-RAY DIFFRACTION (2.7 Å)