2ZLG
The Structual Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase
Summary for 2ZLG
Entry DOI | 10.2210/pdb2zlg/pdb |
Related | 2ZLF |
Descriptor | Ribonucleoside-diphosphate reductase large chain 1, (5R,9S,12S,15S,18S,21S)-21-benzyl-12,18-bis(carboxymethyl)-15-cyclohexyl-1-(9H-fluoren-9-yl)-4-methyl-9-(2-methylpropyl)-3,6,10,13,16,19-hexaoxo-5-phenyl-2-oxa-4,8,11,14,17,20-hexaazadocosan-22-oic acid, GLYCEROL, ... (4 entities in total) |
Functional Keywords | peptidomimetic inhibition eukaryotic ribonucleotide reductase, allosteric enzyme, atp-binding, dna replication, nucleotide-binding, oxidoreductase, phosphoprotein |
Biological source | Saccharomyces cerevisiae (Baker's yeast) |
Cellular location | Cytoplasm: P21524 |
Total number of polymer chains | 1 |
Total formula weight | 100888.33 |
Authors | Xu, H.,Fairman, J.W.,Wijerathna, S.R.,LaMacchia, J.,Kreischer, N.R.,Helmbrecht, E.,Cooperman, B.S.,Dealwis, C. (deposition date: 2008-04-09, release date: 2008-08-19, Last modification date: 2023-11-01) |
Primary citation | Xu, H.,Fairman, J.W.,Wijerathna, S.R.,Kreischer, N.R.,LaMacchia, J.,Helmbrecht, E.,Cooperman, B.S.,Dealwis, C. The Structural Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase: A Conformationally Flexible Pharmacophore J.Med.Chem., 51:4653-4659, 2008 Cited by PubMed: 18610997DOI: 10.1021/jm800350u PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.52 Å) |
Structure validation
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