2ZLG

The Structual Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase

Summary for 2ZLG

• Entry DOI: 10.2210/pdb2zlg/pdb
• Related: 2ZLF
• Descriptor: Ribonucleoside-diphosphate reductase large chain 1, (5R,9S,12S,15S,18S,21S)-21-benzyl-12,18-bis(carboxymethyl)-15-cyclohexyl-1-(9H-fluoren-9-yl)-4-methyl-9-(2-methylpropyl)-3,6,10,13,16,19-hexaoxo-5-phenyl-2-oxa-4,8,11,14,17,20-hexaazadocosan-22-oic acid, GLYCEROL, ... (4 entities in total)
• Functional Keywords: peptidomimetic inhibition eukaryotic ribonucleotide reductase, allosteric enzyme, atp-binding, dna replication, nucleotide-binding, oxidoreductase, phosphoprotein
• Biological source: Saccharomyces cerevisiae (Baker's yeast)
• Cellular location: Cytoplasm: P21524
• Total number of polymer chains: 1
• Total formula weight: 100888.33

Authors

Xu, H.,Fairman, J.W.,Wijerathna, S.R.,LaMacchia, J.,Kreischer, N.R.,Helmbrecht, E.,Cooperman, B.S.,Dealwis, C. (deposition date: 2008-04-09, release date: 2008-08-19, Last modification date: 2023-11-01)

• Primary citation: Xu, H.,Fairman, J.W.,Wijerathna, S.R.,Kreischer, N.R.,LaMacchia, J.,Helmbrecht, E.,Cooperman, B.S.,Dealwis, C.; The Structural Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase: A Conformationally Flexible Pharmacophore; J.Med.Chem., 51:4653-4659, 2008; PubMed: 18610997; DOI: 10.1021/jm800350u

Experimental method

X-RAY DIFFRACTION (2.52 Å)