2ZLG

The Structual Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase

2ZLG の概要

• エントリーDOI: 10.2210/pdb2zlg/pdb
• 関連するPDBエントリー: 2ZLF
• 分子名称: Ribonucleoside-diphosphate reductase large chain 1, (5R,9S,12S,15S,18S,21S)-21-benzyl-12,18-bis(carboxymethyl)-15-cyclohexyl-1-(9H-fluoren-9-yl)-4-methyl-9-(2-methylpropyl)-3,6,10,13,16,19-hexaoxo-5-phenyl-2-oxa-4,8,11,14,17,20-hexaazadocosan-22-oic acid, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: peptidomimetic inhibition eukaryotic ribonucleotide reductase, allosteric enzyme, atp-binding, dna replication, nucleotide-binding, oxidoreductase, phosphoprotein
• 由来する生物種: Saccharomyces cerevisiae (Baker's yeast)
• 細胞内の位置: Cytoplasm: P21524
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 100888.33

構造登録者

Xu, H.,Fairman, J.W.,Wijerathna, S.R.,LaMacchia, J.,Kreischer, N.R.,Helmbrecht, E.,Cooperman, B.S.,Dealwis, C. (登録日: 2008-04-09, 公開日: 2008-08-19, 最終更新日: 2023-11-01)

• 主引用文献: Xu, H.,Fairman, J.W.,Wijerathna, S.R.,Kreischer, N.R.,LaMacchia, J.,Helmbrecht, E.,Cooperman, B.S.,Dealwis, C.; The Structural Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase: A Conformationally Flexible Pharmacophore; J.Med.Chem., 51:4653-4659, 2008; PubMed: 18610997; DOI: 10.1021/jm800350u

実験手法

X-RAY DIFFRACTION (2.52 Å)