2ZLF

The Structural Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase

Summary for 2ZLF

• Entry DOI: 10.2210/pdb2zlf/pdb
• Related: 2ZLG
• Descriptor: Ribonucleoside-diphosphate reductase large chain 1, FTLDADF (3 entities in total)
• Functional Keywords: peptidomimetic inhibition eukaryotic ribonucleotide reductase, allosteric enzyme, atp-binding, cytoplasm, dna replication, nucleotide-binding, oxidoreductase, phosphoprotein
• Biological source: Saccharomyces cerevisiae (Baker's yeast)
• Cellular location: Cytoplasm: P21524
• Total number of polymer chains: 2
• Total formula weight: 100500.86

Authors

Xu, H.,Fairman, J.W.,Wijerathna, S.R.,LaMacchia, J.,Kreischer, N.R.,Helmbrecht, E.,Cooperman, B.S.,Dealwis, C. (deposition date: 2008-04-09, release date: 2008-08-19, Last modification date: 2023-11-01)

• Primary citation: Xu, H.,Fairman, J.W.,Wijerathna, S.R.,Kreischer, N.R.,LaMacchia, J.,Helmbrecht, E.,Cooperman, B.S.,Dealwis, C.; The Structural Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase: A Conformationally Flexible Pharmacophore; J.Med.Chem., 51:4653-4659, 2008; PubMed: 18610997; DOI: 10.1021/jm800350u

Experimental method

X-RAY DIFFRACTION (2.59 Å)