2ZIO

Crystal structure of the catalytic domain of pyrrolysyl-tRNA synthetase in complex with AlocLys-AMP and PNP

2ZIO の概要

• エントリーDOI: 10.2210/pdb2zio/pdb
• 関連するPDBエントリー: 2E3C 2ZCD 2ZCE 2ZIN
• 分子名称: Pyrrolysyl-tRNA synthetase, IMIDODIPHOSPHORIC ACID, 5'-O-[(S)-({(2S)-2-amino-6-[(propoxycarbonyl)amino]hexanoyl}oxy)(hydroxy)phosphoryl]adenosine, ... (4 entities in total)
• 機能のキーワード: aminoacyl-trna synthetase, pyrrolysyl-trna synthetase, trna, pyrrolysine, atp analogue, non-natural amino acid, unnatural amino acid, atp-binding, cytoplasm, ligase, nucleotide-binding, protein biosynthesis, structural genomics, nppsfa, national project on protein structural and functional analyses, riken structural genomics/proteomics initiative, rsgi
• 由来する生物種: Methanosarcina mazei
• 細胞内の位置: Cytoplasm (By similarity): Q8PWY1
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34082.64

構造登録者

Yanagisawa, T.,Ishii, R.,Yokoyama, S.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (登録日: 2008-02-19, 公開日: 2008-12-02, 最終更新日: 2023-11-01)

• 主引用文献: Yanagisawa, T.,Ishii, R.,Fukunaga, R.,Kobayashi, T.,Sakamoto, K.,Yokoyama, S.; Multistep Engineering of Pyrrolysyl-tRNA Synthetase to Genetically Encode N(varepsilon)-(o-Azidobenzyloxycarbonyl) lysine for Site-Specific Protein Modification; Chem.Biol., 15:1187-1197, 2008; PubMed: 19022179; DOI: 10.1016/j.chembiol.2008.10.004

実験手法

X-RAY DIFFRACTION (2.06 Å)