2ZFH
Crystal structure of putative CutA1 from Homo sapiens at 2.05A resolution
Summary for 2ZFH
| Entry DOI | 10.2210/pdb2zfh/pdb |
| Related | 1XK8 |
| Descriptor | CutA (2 entities in total) |
| Functional Keywords | human brain, trimeric structure, structural genomics, nppsfa, national project on protein structural and functional analyses, riken structural genomics/proteomics initiative, rsgi, unknown function |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 6 |
| Total formula weight | 114781.38 |
| Authors | Bagautdinov, B.,Yutani, K.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (deposition date: 2008-01-07, release date: 2008-01-22, Last modification date: 2023-11-01) |
| Primary citation | Bagautdinov, B.,Matsuura, Y.,Bagautdinova, S.,Kunishima, N.,Yutani, K. Structure of putative CutA1 from Homo sapiens determined at 2.05 A resolution. Acta Crystallogr.,Sect.F, 64:351-357, 2008 Cited by PubMed Abstract: The structure of human brain CutA1 (HsCutA1) has been determined using diffraction data to 2.05 A resolution. HsCutA1 has been implicated in the anchoring of acetylcholinesterase in neuronal cell membranes, while its bacterial homologue Escherichia coli CutA1 is involved in copper tolerance. Additionally, the structure of HsCutA1 bears similarity to that of the signal transduction protein PII, which is involved in regulation of nitrogen metabolism. Although several crystal structures of CutA1 from various sources with different rotation angles and degrees of interaction between trimer interfaces have been reported, the specific functional role of CutA1 is still unclear. In this study, the X-ray structure of HsCutA1 was determined in space group P2(1)2(1)2(1), with unit-cell parameters a = 68.69, b = 88.84, c = 125.33 A and six molecules per asymmetric unit. HsCutA1 is a trimeric molecule with intertwined antiparallel beta-strands; each subunit has a molecular weight of 14.6 kDa and contains 135 amino-acid residues. In order to obtain clues to the possible function of HsCutA1, its crystal structure was compared with those of other CutA1 and PII proteins. PubMed: 18453701DOI: 10.1107/S1744309108009846 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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