2ZDZ

X-ray structure of Bace-1 in complex with compound 3.b.10

Summary for 2ZDZ

Entry DOI	10.2210/pdb2zdz/pdb
Related	2QU2 2QU3
Descriptor	Beta-secretase 1, N-carbamimidoyl-2-[2-(2-chlorophenyl)-5-[4-(4-ethanoylphenoxy)phenyl]pyrrol-1-yl]ethanamide (3 entities in total)
Functional Keywords	bace, aspartyl protease, acylguanidine inhibitor, alternative splicing, glycoprotein, hydrolase, membrane, transmembrane, zymogen
Biological source	Homo sapiens (Human)
Cellular location	Membrane; Single-pass type I membrane protein: P56817
Total number of polymer chains	1
Total formula weight	46927.93
Authors	Chopra, R.,Olland, A. (deposition date: 2007-12-04, release date: 2008-12-09, Last modification date: 2011-07-13)
Primary citation	Cole, D.C.,Stock, J.R.,Chopra, R.,Cowling, R.,Ellingboe, J.W.,Fan, K.Y.,Harrison, B.L.,Hu, Y.,Jacobsen, S.,Jennings, L.D.,Jin, G.,Lohse, P.A.,Malamas, M.S.,Manas, E.S.,Moore, W.J.,O'Donnell, M.M.,Olland, A.M.,Robichaud, A.J.,Svenson, K.,Wu, J.,Wagner, E.,Bard, J. Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets. Bioorg.Med.Chem.Lett., 18:1063-1066, 2008 Cited by PubMed: 18162398 DOI: 10.1016/j.bmcl.2007.12.010 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation