2ZB6

Crystal structure of the measles virus hemagglutinin (oligo-sugar type)

2ZB6 の概要

• エントリーDOI: 10.2210/pdb2zb6/pdb
• 関連するPDBエントリー: 2ZB5
• 分子名称: Hemagglutinin protein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: beta propeller, envelope protein, hemagglutinin, membrane, transmembrane, virion, viral protein
• 由来する生物種: Measles virus strain Edmonston-B
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 54069.26

構造登録者

Hashiguchi, T.,Kajikawa, M.,Maita, N.,Takeda, M.,Kuroki, K.,Sasaki, K.,Kohda, D.,Yanagi, Y.,Maenaka, K. (登録日: 2007-10-16, 公開日: 2007-11-06, 最終更新日: 2024-10-23)

主引用文献

Hashiguchi, T.,Kajikawa, M.,Maita, N.,Takeda, M.,Kuroki, K.,Sasaki, K.,Kohda, D.,Yanagi, Y.,Maenaka, K.
Crystal structure of measles virus hemagglutinin provides insight into effective vaccines
Proc.Natl.Acad.Sci.Usa, 104:19535-19540, 2007

PubMed Abstract: Measles still remains a major cause of childhood morbidity and mortality worldwide. Measles virus (MV) vaccines are highly successful, but the mechanism underlying their efficacy has been unclear. Here we report the crystal structure of the MV attachment protein, hemagglutinin, responsible for MV entry. The receptor-binding head domain exhibits a cubic-shaped beta-propeller structure and forms a homodimer. N-linked sugars appear to mask the broad regions and cause the two molecules forming the dimer to tilt oppositely toward the horizontal plane. Accordingly, residues of the putative receptor-binding site, highly conserved among MV strains, are strategically positioned in the unshielded area of the protein. These conserved residues also serve as epitopes for neutralizing antibodies, ensuring the serological monotype, a basis for effective MV vaccines. Our findings suggest that sugar moieties in the MV hemagglutinin critically modulate virus-receptor interaction as well as antiviral antibody responses, differently from sugars of the HIV gp120, which allow for immune evasion.

PubMed: 18003910
DOI: 10.1073/pnas.0707830104

実験手法

X-RAY DIFFRACTION (2.6 Å)