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2Z78

S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with BPH-806

Summary for 2Z78
Entry DOI10.2210/pdb2z78/pdb
DescriptorGeranylgeranyl pyrophosphate synthetase, 3-(decyloxy)-5-(3,5-difluorophenyl)-1-(2,2-diphosphonoethyl)pyridinium (3 entities in total)
Functional Keywordsprenyltransferase, geranylgeranyl pyrophosphate, bisphosphonate, carotenoid biosynthesis, isoprene biosynthesis, multifunctional enzyme, protein transport, transport, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceSaccharomyces cerevisiae (Baker's yeast)
Cellular locationCytoplasm (By similarity): Q12051
Total number of polymer chains2
Total formula weight79671.04
Authors
Chen, C.K.-M.,Guo, R.T.,Hudock, M.,Cao, R.,Oldfield, E.,Wang, A.H.-J. (deposition date: 2007-08-16, release date: 2008-07-08, Last modification date: 2023-11-01)
Primary citationChen, C.K.-M.,Hudock, M.P.,Zhang, Y.,Guo, R.-T.,Cao, R.,No, J.H.,Liang, P.-H.,Ko, T.-P.,Chang, T.-H.,Chang, S.-C.,Song, Y.,Axelson, J.,Kumar, A.,Wang, A.H.-J.,Oldfield, E.
Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation
J.Med.Chem., 51:5594-5607, 2008
Cited by
PubMed: 18800762
DOI: 10.1021/jm800325y
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

217705

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