2Z78

S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with BPH-806

2Z78 の概要

• エントリーDOI: 10.2210/pdb2z78/pdb
• 分子名称: Geranylgeranyl pyrophosphate synthetase, 3-(decyloxy)-5-(3,5-difluorophenyl)-1-(2,2-diphosphonoethyl)pyridinium (3 entities in total)
• 機能のキーワード: prenyltransferase, geranylgeranyl pyrophosphate, bisphosphonate, carotenoid biosynthesis, isoprene biosynthesis, multifunctional enzyme, protein transport, transport, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Saccharomyces cerevisiae (Baker's yeast)
• 細胞内の位置: Cytoplasm (By similarity): Q12051
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 79671.04

構造登録者

Chen, C.K.-M.,Guo, R.T.,Hudock, M.,Cao, R.,Oldfield, E.,Wang, A.H.-J. (登録日: 2007-08-16, 公開日: 2008-07-08, 最終更新日: 2023-11-01)

• 主引用文献: Chen, C.K.-M.,Hudock, M.P.,Zhang, Y.,Guo, R.-T.,Cao, R.,No, J.H.,Liang, P.-H.,Ko, T.-P.,Chang, T.-H.,Chang, S.-C.,Song, Y.,Axelson, J.,Kumar, A.,Wang, A.H.-J.,Oldfield, E.; Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation; J.Med.Chem., 51:5594-5607, 2008; PubMed: 18800762; DOI: 10.1021/jm800325y

実験手法

X-RAY DIFFRACTION (2.1 Å)