2Z35

Crystal structure of immune receptor

2Z35 の概要

• エントリーDOI: 10.2210/pdb2z35/pdb
• 分子名称: T-cell receptor alpha-chain, T-cell receptor beta-chain (3 entities in total)
• 機能のキーワード: immune receptor, immune system
• 由来する生物種: Mus musculus (house mouse); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 24475.75

構造登録者

Feng, D.,Bond, C.J.,Ely, L.K.,Garcia, K.C. (登録日: 2007-06-01, 公開日: 2007-10-09, 最終更新日: 2024-10-30)

主引用文献

Feng, D.,Bond, C.J.,Ely, L.K.,Maynard, J.,Garcia, K.C.
Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'
Nat.Immunol., 8:975-983, 2007

PubMed Abstract: All complexes of T cell receptors (TCRs) bound to peptide-major histocompatibility complex (pMHC) molecules assume a stereotyped binding 'polarity', despite wide variations in TCR-pMHC docking angles. However, existing TCR-pMHC crystal structures have failed to show broadly conserved pairwise interaction motifs. Here we determined the crystal structures of two TCRs encoded by the variable beta-chain 8.2 (V(beta)8.2), each bound to the MHC class II molecule I-A(u), and did energetic mapping of V(alpha) and V(beta) contacts with I-A(u). Together with two previously solved structures of V(beta)8.2-containing TCR-MHC complexes, we found four TCR-I-A complexes with structurally superimposable interactions between the V(beta) loops and the I-A alpha-helix. This examination of a narrow 'slice' of the TCR-MHC repertoire demonstrates what is probably one of many germline-derived TCR-MHC interaction 'codons'.

PubMed: 17694060
DOI: 10.1038/ni1502

実験手法

X-RAY DIFFRACTION (2.2 Å)