Crystal structure of Humanized HYHEL-10 FV mutant(HQ39KW47Y)-HEN lysozyme complex

Summary for 2YSS

Related2EIZ 2EKS
DescriptorANTI-LYSOZYME ANTIBODY FV REGION, Lysozyme C, ... (4 entities in total)
Functional Keywordsimmune system, hydrolase, immune system-hydrolase complex, immune system/hydrolase
Biological sourceHomo sapiens (human)
Cellular locationSecreted P00698
Total number of polymer chains3
Total molecular weight38447.95
Nakanishi, T.,Tsumoto, K.,Yokota, A.,Kondo, H.,Kumagai, I. (deposition date: 2007-04-03, release date: 2008-04-08, Last modification date: 2017-10-25)
Primary citation
Nakanishi, T.,Tsumoto, K.,Yokota, A.,Kondo, H.,Kumagai, I.
Critical contribution of VH-VL interaction to reshaping of an antibody: the case of humanization of anti-lysozyme antibody, HyHEL-10
Protein Sci., 17:261-270, 2008
PubMed: 18227432 (PDB entries with the same primary citation)
DOI: 10.1110/ps.073156708
MImport into Mendeley
Experimental method
NMR Information

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.265141.5%3.7%5.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report