2YJ7

Crystal structure of a hyperstable protein from the Precambrian period

2YJ7 の概要

• エントリーDOI: 10.2210/pdb2yj7/pdb
• 関連するPDBエントリー: 2YN1 2YNX 2YOI 2YPM 3ZIV 4BA7
• 分子名称: LPBCA THIOREDOXIN, SODIUM ION (3 entities in total)
• 機能のキーワード: oxidoreductase
• 由来する生物種: SYNTHETIC CONSTRUCT
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 24034.76

構造登録者

Gavira, J.A.,Ingles, A.,Ibarra, B.,Garcia-Ruiz, J.M. (登録日: 2011-05-19, 公開日: 2012-05-30, 最終更新日: 2024-11-13)

主引用文献

Ingles-Prieto, A.,Ibarra-Molero, B.,Delgado-Delgado, A.,Perez-Jimenez, R.,Fernandez, J.M.,Gaucher, E.A.,Sanchez-Ruiz, J.M.,Gavira, J.A.
Conservation of Protein Structure Over Four Billion Years
Structure, 21:1690-, 2013

PubMed Abstract: Little is known about the evolution of protein structures and the degree of protein structure conservation over planetary time scales. Here, we report the X-ray crystal structures of seven laboratory resurrections of Precambrian thioredoxins dating up to approximately four billion years ago. Despite considerable sequence differences compared with extant enzymes, the ancestral proteins display the canonical thioredoxin fold, whereas only small structural changes have occurred over four billion years. This remarkable degree of structure conservation since a time near the last common ancestor of life supports a punctuated-equilibrium model of structure evolution in which the generation of new folds occurs over comparatively short periods and is followed by long periods of structural stasis.

PubMed: 23932589
DOI: 10.1016/J.STR.2013.06.020

実験手法

X-RAY DIFFRACTION (1.65 Å)