2YEP

STRUCTURE OF AN N-TERMINAL NUCLEOPHILE (NTN) HYDROLASE, OAT2, IN COMPLEX WITH GLUTAMATE

「2W4N」から置き換えられました

2YEP の概要

• エントリーDOI: 10.2210/pdb2yep/pdb
• 関連するPDBエントリー: 1VZ6 1VZ7 1VZ8 2V4I 2VZK 2W4N
• 分子名称: GLUTAMATE N-ACETYLTRANSFERASE 2 ALPHA CHAIN, GLUTAMATE N-ACETYLTRANSFERASE 2 BETA CHAIN, GLUTAMIC ACID, ... (6 entities in total)
• 機能のキーワード: acyl enzyme, transferase, ntn hydrolase, acyltransferase, ornithine acetyl transferase, hydrolase
• 由来する生物種: STREPTOMYCES CLAVULIGERUS; 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 167225.22

構造登録者

Chowdhury, R.,Iqbal, A.,Clifton, I.J.,Schofield, C.J. (登録日: 2011-03-29, 公開日: 2011-09-07, 最終更新日: 2024-11-13)

主引用文献

Iqbal, A.,Clifton, I.J.,Chowdhury, R.,Ivison, D.,Domene, C.,Schofield, C.J.
Structural and Biochemical Analyses Reveal How Ornithine Acetyl Transferase Binds Acidic and Basic Amino Acid Substrates.
Org.Biomol.Chem., 9:6219-, 2011

PubMed Abstract: Structural and biochemical analyses reveal how ornithine acetyl-transferases catalyse the reversible transfer of an acetyl-group from a basic (ornithine) to an acidic (glutamate) amino acid by employing a common mechanism involving an acetyl-enzyme intermediate but using different side chain binding modes.

PubMed: 21796301
DOI: 10.1039/C1OB05554B

実験手法

X-RAY DIFFRACTION (2.7 Å)