2YAW

HG INHIBITED SULFUR OXYGENASE REDUCTASE

2YAW の概要

• エントリーDOI: 10.2210/pdb2yaw/pdb
• 関連するPDBエントリー: 2CB2 2YAV 2YAX
• 分子名称: SULFUR OXYGENASE/REDUCTASE, FE (III) ION, MERCURY (II) ION, ... (5 entities in total)
• 機能のキーワード: oxidoreductase, mononuclear non-heme iron, biogeochemical sulfur cycle, thermophilic, cysteine persulphide, icosatetramer
• 由来する生物種: ACIDIANUS AMBIVALENS
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 221574.44

構造登録者

Veith, A.,Urich, T.,Seyfarth, K.,Protze, J.,Frazao, C.,Kletzin, A. (登録日: 2011-02-25, 公開日: 2011-12-21, 最終更新日: 2024-11-20)

主引用文献

Veith, A.,Urich, T.,Seyfarth, K.,Protze, J.,Frazao, C.,Kletzin, A.
Substrate Pathways and Mechanisms of Inhibition in the Sulfur Oxygenase Reductase of Acidianus Ambivalens.
Front.Microbiol., 2:37-, 2011

PubMed Abstract: The sulfur oxygenase reductase (SOR) is the initial enzyme of the sulfur oxidation pathway in the thermoacidophilic Archaeon Acidianus ambivalens. The SOR catalyzes an oxygen-dependent sulfur disproportionation to H(2)S, sulfite and thiosulfate. The spherical, hollow, cytoplasmic enzyme is composed of 24 identical subunits with an active site pocket each comprising a mononuclear non-heme iron site and a cysteine persulfide. Substrate access and product exit occur via apolar chimney-like protrusions at the fourfold symmetry axes, via narrow polar pores at the threefold symmetry axes and via narrow apolar pores within in each subunit. In order to investigate the function of the pores we performed site-directed mutagenesis and inhibitor studies.

PubMed: 21747782
DOI: 10.3389/FMICB.2011.00037

実験手法

X-RAY DIFFRACTION (2.499 Å)