2YAK

Structure of death-associated protein Kinase 1 (dapk1) in complex with a ruthenium octasporine ligand (OSV)

2YAK の概要

• エントリーDOI: 10.2210/pdb2yak/pdb
• 関連するPDBエントリー: 1IG1 1JKK 1JKL 1JKS 1JKT 1P4F 2W4J 2W4K 2X0G 2XUU 2XZS 2Y0A 2Y4P 2Y4V
• 分子名称: DEATH-ASSOCIATED PROTEIN KINASE 1, RUTHENIUM OCTASPORINE 4 (3 entities in total)
• 機能のキーワード: transferase, octahedral ruthenium inhibitory complex, kinase inhibitor
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Cytoplasm: P53355
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33433.15

構造登録者

Feng, L.,Geisselbrecht, Y.,Blanck, S.,Wilbuer, A.,Atilla-Gokcumen, G.E.,Filippakopoulos, P.,Kraeling, K.,Celik, M.A.,Harms, K.,Maksimoska, J.,Marmorstein, R.,Frenking, G.,Knapp, S.,Essen, L.-O.,Meggers, E. (登録日: 2011-02-23, 公開日: 2011-04-27, 最終更新日: 2011-07-13)

• 主引用文献: Feng, L.,Geisselbrecht, Y.,Blanck, S.,Wilbuer, A.,Atilla-Gokcumen, G.E.,Filippakopoulos, P.,Kraeling, K.,Celik, M.A.,Harms, K.,Maksimoska, J.,Marmorstein, R.,Frenking, G.,Knapp, S.,Essen, L.O.,Meggers, E.; Structurally Sophisticated Octahedral Metal Complexes as Highly Selective Protein Kinase Inhibitors.; J.Am.Chem.Soc., 133:5976-, 2011; PubMed: 21446733; DOI: 10.1021/JA1112996

実験手法

X-RAY DIFFRACTION (2.2 Å)