2Y8P

Crystal Structure of an Outer Membrane-Anchored Endolytic Peptidoglycan Lytic Transglycosylase (MltE) from Escherichia coli

2Y8P の概要

• エントリーDOI: 10.2210/pdb2y8p/pdb
• 分子名称: ENDO-TYPE MEMBRANE-BOUND LYTIC MUREIN TRANSGLYCOSYLASE A (2 entities in total)
• 機能のキーワード: lyase, cell wall biogenesis/degradation
• 由来する生物種: ESCHERICHIA COLI
• 細胞内の位置: Cell outer membrane; Lipid-anchor (Probable): P0C960
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 42828.62

構造登録者

Artola-Recolons, C.,Carrasco-Lopez, C.,Llarrull, L.I.,Kumarasiri, M.,Lastochkin, E.,Martinez-Ilarduya, I.,Meindl, K.,Uson, I.,Mobashery, S.,Hermoso, J.A. (登録日: 2011-02-08, 公開日: 2011-04-13, 最終更新日: 2024-05-08)

主引用文献

Artola-Recolons, C.,Carrasco-Lopez, C.,Llarrull, L.I.,Kumarasiri, M.,Lastochkin, E.,Martinez De Ilarduya, I.,Meindl, K.,Uson, I.,Mobashery, S.,Hermoso, J.A.
High-Resolution Crystal Structure of Mlte, an Outer Membrane-Anchored Endolytic Peptidoglycan Lytic Transglycosylase from Escherichia Coli.
Biochemistry, 50:2384-, 2011

PubMed Abstract: The crystal structure of the first endolytic peptidoglycan lytic transglycosylase MltE from Escherichia coli is reported here. The degradative activity of this enzyme initiates the process of cell wall recycling, which is an integral event in the existence of bacteria. The structure sheds light on how MltE recognizes its substrate, the cell wall peptidoglycan. It also explains the ability of this endolytic enzyme to cleave in the middle of the peptidoglycan chains. Furthermore, the structure reveals how the enzyme is sequestered on the inner leaflet of the outer membrane.

PubMed: 21341761
DOI: 10.1021/BI200085Y

実験手法

X-RAY DIFFRACTION (1.995 Å)