2Y6D

The Discovery of MMP7 Inhibitors Exploiting a Novel Selectivity Trigger

Summary for 2Y6D

• Entry DOI: 10.2210/pdb2y6d/pdb
• Related: 1MMP 1MMQ 1MMR 2Y6C
• Descriptor: MATRILYSIN, CALCIUM ION, ZINC ION, ... (6 entities in total)
• Functional Keywords: hydrolase
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Secreted, extracellular space, extracellular matrix (Probable): P09237
• Total number of polymer chains: 1
• Total formula weight: 20131.03

Authors

Edman, K.,Furber, M.,Hemsley, P.,Johansson, C.,Pairaudeau, G.,Petersen, J.,Stocks, M.,Tervo, A.,Ward, A.,Wells, E.,Wissler, L. (deposition date: 2011-01-20, release date: 2011-05-04, Last modification date: 2024-05-08)

• Primary citation: Edman, K.,Furber, M.,Hemsley, P.,Johansson, C.,Pairaudeau, G.,Petersen, J.,Stocks, M.,Tervo, A.,Ward, A.,Wells, E.,Wissler, L.; The Discovery of Mmp7 Inhibitors Exploiting a Novel Selectivity Trigger.; Chemmedchem, 6:769-, 2011; PubMed: 21520417; DOI: 10.1002/CMDC.201000550

Experimental method

X-RAY DIFFRACTION (1.6 Å)