2Y2F

Crystal structure of Yersinia pestis YopH in complex with an aminooxy- containing platform compound for inhibitor design

2Y2F の概要

• エントリーDOI: 10.2210/pdb2y2f/pdb
• 関連するPDBエントリー: 1QZ0
• 分子名称: PROTEIN-TYROSINE PHOSPHATASE YOPH, [4-[3-(DIFLUORO-PHOSPHONO-METHYL)PHENYL]PHENYL]METHOXYAZANIUM (3 entities in total)
• 機能のキーワード: hydrolase, protein tyrosine phosphatase
• 由来する生物種: YERSINIA PESTIS
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33884.13

構造登録者

Lountos, G.T.,Bahta, M.,Dyas, B.,Ulrich, R.G.,Waugh, D.S.,Burke, T.R. (登録日: 2010-12-14, 公開日: 2011-03-16, 最終更新日: 2023-12-20)

• 主引用文献: Bahta, M.,Lountos, G.T.,Dyas, B.,Kim, S.,Ulrich, R.G.,Waugh, D.S.,Burke, T.R.; Utilization of Nitrophenylphosphates and Oxime-Based Ligation for the Development of Nanomolar Affinity Inhibitors of the Yersinia Pestis Outer Protein H (Yoph) Phosphatase.; J.Med.Chem., 54:2933-, 2011; PubMed: 21443195; DOI: 10.1021/JM200022G

実験手法

X-RAY DIFFRACTION (1.78 Å)