2XYN

HUMAN ABL2 IN COMPLEX WITH AURORA KINASE INHIBITOR VX-680

「3NSV」から置き換えられました

2XYN の概要

• エントリーDOI: 10.2210/pdb2xyn/pdb
• 分子名称: TYROSINE-PROTEIN KINASE ABL2, SODIUM ION, CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE, ... (5 entities in total)
• 機能のキーワード: cell adhesion, structural genomics consortium, sgc, transferase
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 103963.61

構造登録者

Salah, E.,Ugochukwu, E.,Elkins, J.M.,Barr, A.J.,Shrestha, B.,Savitsky, P.,Mahajan, P.,Muniz, J.R.C.,Yue, W.W.,Chaikuad, A.,von Delft, F.,Bountra, C.,Arrowsmith, C.H.,Weigelt, J.,Edwards, A.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2010-11-18, 公開日: 2010-12-01, 最終更新日: 2023-12-20)

• 主引用文献: Salah, E.,Ugochukwu, E.,Barr, A.J.,von Delft, F.,Knapp, S.,Elkins, J.M.; Crystal Structures of Abl-Related Gene (Abl2) in Complex with Imatinib, Tozasertib (Vx-680), and a Type I Inhibitor of the Triazole Carbothioamide Class.; J.Med.Chem., 54:2359-, 2011; PubMed: 21417343; DOI: 10.1021/JM101506N

実験手法

X-RAY DIFFRACTION (2.81 Å)