2XTB
Crystal Structure of Trypanosoma brucei rhodesiense Adenosine Kinase Complexed with Activator
Summary for 2XTB
| Entry DOI | 10.2210/pdb2xtb/pdb |
| Descriptor | ADENOSINE KINASE, 4-[5-(4-PHENOXYPHENYL)-1H-PYRAZOL-3-YL]MORPHOLINE (3 entities in total) |
| Functional Keywords | transferase |
| Biological source | TRYPANOSOMA BRUCEI RHODESIENSE |
| Total number of polymer chains | 1 |
| Total formula weight | 38452.85 |
| Authors | Kuettel, S.,Greenwald, J.,Kostrewa, D.,Ahmed, S.,Scapozza, L.,Perozzo, R. (deposition date: 2010-10-05, release date: 2011-06-29, Last modification date: 2024-05-08) |
| Primary citation | Kuettel, S.,Greenwald, J.,Kostrewa, D.,Ahmed, S.,Scapozza, L.,Perozzo, R. Crystal Structures of T. B. Rhodesiense Adenosine Kinase Complexed with Inhibitor and Activator: Implications for Catalysis and Hyperactivation. Plos Negl Trop Dis, 5:E1164-, 2011 Cited by PubMed Abstract: The essential purine salvage pathway of Trypanosoma brucei bears interesting catalytic enzymes for chemotherapeutic intervention of Human African Trypanosomiasis. Unlike mammalian cells, trypanosomes lack de novo purine synthesis and completely rely on salvage from their hosts. One of the key enzymes is adenosine kinase which catalyzes the phosphorylation of ingested adenosine to form adenosine monophosphate (AMP) utilizing adenosine triphosphate (ATP) as the preferred phosphoryl donor. PubMed: 21629723DOI: 10.1371/JOURNAL.PNTD.0001164 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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