2XPB
DISCOVERY OF CELL-ACTIVE PHENYL-IMIDAZOLE PIN1 INHIBITORS BY STRUCTURE-GUIDED FRAGMENT EVOLUTION
2XPB の概要
エントリーDOI | 10.2210/pdb2xpb/pdb |
関連するPDBエントリー | 1F8A 1I6C 1I8G 1I8H 1NMV 1NMW 1PIN 1ZCN 2F21 2XP3 2XP4 2XP5 2XP6 2XP7 2XP8 2XP9 2XPA |
分子名称 | PEPTIDYL-PROLYL CIS-TRANS ISOMERASE NIMA-INTERACTING 1, DODECAETHYLENE GLYCOL, 5-[BENZYL(METHYL)CARBAMOYL]-2-(3-CHLOROPHENYL)-1H-IMIDAZOLE-4-CARBOXYLIC ACID, ... (4 entities in total) |
機能のキーワード | isomerase, proline directed kinase, cell cycle, oncogenic transformation |
由来する生物種 | HOMO SAPIENS (HUMAN) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 19440.97 |
構造登録者 | Potter, A.,Oldfield, V.,Nunns, C.,Fromont, C.,Ray, S.,Northfield, C.J.,Bryant, C.J.,Scrace, S.F.,Robinson, D.,Matossova, N.,Baker, L.,Dokurno, P.,Surgenor, A.E.,Davis, B.E.,Richardson, C.M.,Murray, J.B.,Moore, J.D. (登録日: 2010-08-25, 公開日: 2011-01-12, 最終更新日: 2023-12-20) |
主引用文献 | Potter, A.,Oldfield, V.,Nunns, C.,Fromont, C.,Ray, S.,Northfield, C.J.,Bryant, C.J.,Scrace, S.F.,Robinson, D.,Matossova, N.,Baker, L.,Dokurno, P.,Surgenor, A.E.,Davis, B.E.,Richardson, C.M.,Murray, J.B.,Moore, J.D. Discovery of Cell-Active Phenyl-Imidazole Pin1 Inhibitors by Structure-Guided Fragment Evolution. Bioorg.Med.Chem.Lett., 20:6483-, 2010 Cited by PubMed: 20932746DOI: 10.1016/J.BMCL.2010.09.063 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2 Å) |
構造検証レポート
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