2XL4

LntA, a virulence factor from Listeria monocytogenes

Summary for 2XL4

• Entry DOI: 10.2210/pdb2xl4/pdb
• Descriptor: Listeria nuclear targeted protein A, GLYCEROL (3 entities in total)
• Functional Keywords: toxin, immune system
• Biological source: Listeria monocytogenes serovar 1/2a
• Total number of polymer chains: 1
• Total formula weight: 20341.66

Authors

Lebreton, A.,Job, V.,Tham, T.N.,Camejo, A.,Mattei, P.J.,Regnault, B.,Cabanes, D.,Dessen, A.,Cossart, P.,Bierne, H. (deposition date: 2010-07-19, release date: 2011-02-02, Last modification date: 2024-11-13)

Primary citation

Lebreton, A.,Lakisic, G.,Job, V.,Fritsch, L.,Tham, T.N.,Camejo, A.,Mattei, P.J.,Regnault, B.,Nahori, M.A.,Cabanes, D.,Gautreau, A.,Ait-Si-Ali, S.,Dessen, A.,Cossart, P.,Bierne, H.
A bacterial protein targets the BAHD1 chromatin complex to stimulate type III interferon response.
Science, 331:1319-1321, 2011

PubMed Abstract: Intracellular pathogens such as Listeria monocytogenes subvert cellular functions through the interaction of bacterial effectors with host components. Here we found that a secreted listerial virulence factor, LntA, could target the chromatin repressor BAHD1 in the host cell nucleus to activate interferon (IFN)-stimulated genes (ISGs). IFN-λ expression was induced in response to infection of epithelial cells with bacteria lacking LntA; however, the BAHD1-chromatin associated complex repressed downstream ISGs. In contrast, in cells infected with lntA-expressing bacteria, LntA prevented BAHD1 recruitment to ISGs and stimulated their expression. Murine listeriosis decreased in BAHD1(+/-) mice or when lntA was constitutively expressed. Thus, the LntA-BAHD1 interplay may modulate IFN-λ-mediated immune response to control bacterial colonization of the host.

PubMed: 21252314
DOI: 10.1126/science.1200120

Experimental method

X-RAY DIFFRACTION (2.3 Å)