2XKV

Atomic Model of the SRP-FtsY Early Conformation

Summary for 2XKV

Entry DOI	10.2210/pdb2xkv/pdb
Related	1DUL 1FFH 1HQ1 1JPJ 1JPN 1LS1 1NG1 1O87 1OKK 1RJ9 1RY1 2C03 2C04 2CNW 2FFH 2IY3 2IYL 2J28 2J45 2J46 2J7P 2NG1 3NG1
EMDB information	1762
Descriptor	SIGNAL RECOGNITION PARTICLE PROTEIN, 4.5S RNA, CELL DIVISION PROTEIN FTSY, ... (4 entities in total)
Functional Keywords	protein transport
Biological source	ESCHERICHIA COLI More
Cellular location	Cytoplasm : O07347 P0AGD7 Cell membrane; Peripheral membrane protein; Cytoplasmic side: P83749
Total number of polymer chains	4
Total formula weight	110290.23
Authors	Estrozi, L.F.,Boehringer, D.,Shan, S.-o.,Ban, N.,Schaffitzel, C. (deposition date: 2010-07-13, release date: 2010-12-15, Last modification date: 2024-05-08)
Primary citation	Estrozi, L.F.,Boehringer, D.,Shan, S.-O.,Ban, N.,Schaffitzel, C. Cryo-Em Structure of the E. Coli Translating Ribosome in Complex with Srp and its Receptor. Nat.Struct.Mol.Biol., 18:88-, 2011 Cited by PubMed Abstract: We report the 'early' conformation of the Escherichia coli signal recognition particle (SRP) and its receptor FtsY bound to the translating ribosome, as determined by cryo-EM. FtsY binds to the tetraloop of the SRP RNA, whereas the NG domains of the SRP protein and FtsY interact weakly in this conformation. Our results suggest that optimal positioning of the SRP RNA tetraloop and the Ffh NG domain leads to FtsY recruitment. PubMed: 21151118 DOI: 10.1038/NSMB.1952 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (13.5 Å)

Structure validation