2XKV

Atomic Model of the SRP-FtsY Early Conformation

2XKV の概要

• エントリーDOI: 10.2210/pdb2xkv/pdb
• 関連するPDBエントリー: 1DUL 1FFH 1HQ1 1JPJ 1JPN 1LS1 1NG1 1O87 1OKK 1RJ9 1RY1 2C03 2C04 2CNW 2FFH 2IY3 2IYL 2J28 2J45 2J46 2J7P 2NG1 3NG1
• EMDBエントリー: 1762
• 分子名称: SIGNAL RECOGNITION PARTICLE PROTEIN, 4.5S RNA, CELL DIVISION PROTEIN FTSY, ... (4 entities in total)
• 機能のキーワード: protein transport
• 由来する生物種: ESCHERICHIA COLI; 詳細
• 細胞内の位置: Cytoplasm : O07347 P0AGD7; Cell membrane; Peripheral membrane protein; Cytoplasmic side: P83749
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 110290.23

構造登録者

Estrozi, L.F.,Boehringer, D.,Shan, S.-o.,Ban, N.,Schaffitzel, C. (登録日: 2010-07-13, 公開日: 2010-12-15, 最終更新日: 2024-05-08)

主引用文献

Estrozi, L.F.,Boehringer, D.,Shan, S.-O.,Ban, N.,Schaffitzel, C.
Cryo-Em Structure of the E. Coli Translating Ribosome in Complex with Srp and its Receptor.
Nat.Struct.Mol.Biol., 18:88-, 2011

PubMed Abstract: We report the 'early' conformation of the Escherichia coli signal recognition particle (SRP) and its receptor FtsY bound to the translating ribosome, as determined by cryo-EM. FtsY binds to the tetraloop of the SRP RNA, whereas the NG domains of the SRP protein and FtsY interact weakly in this conformation. Our results suggest that optimal positioning of the SRP RNA tetraloop and the Ffh NG domain leads to FtsY recruitment.

PubMed: 21151118
DOI: 10.1038/NSMB.1952

実験手法

ELECTRON MICROSCOPY (13.5 Å)