2XK9
Structural analysis of checkpoint kinase 2 (Chk2) in complex with inhibitor PV1533
Summary for 2XK9
Entry DOI | 10.2210/pdb2xk9/pdb |
Descriptor | CHECKPOINT KINASE 2, N-{4-[(1E)-N-(N-hydroxycarbamimidoyl)ethanehydrazonoyl]phenyl}-7-nitro-1H-indole-2-carboxamide (3 entities in total) |
Functional Keywords | structure-based drug design, transferase |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 36826.42 |
Authors | Lountos, G.T.,Jobson, A.G.,Tropea, J.E.,Self, C.,Shoemaker, R.H.,Pommier, Y.,Waugh, D.S. (deposition date: 2010-07-07, release date: 2011-07-20, Last modification date: 2023-12-20) |
Primary citation | Lountos, G.T.,Jobson, A.G.,Tropea, J.E.,Self, C.R.,Zhang, G.,Pommier, Y.,Shoemaker, R.H.,Waugh, D.S. Structural Characterization of Inhibitor Complexes with Checkpoint Kinase 2 (Chk2), a Drug Target for Cancer Therapy. J.Struct.Biol., 176:292-, 2011 Cited by PubMed: 21963792DOI: 10.1016/J.JSB.2011.09.008 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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