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2XK9

Structural analysis of checkpoint kinase 2 (Chk2) in complex with inhibitor PV1533

Summary for 2XK9
Entry DOI10.2210/pdb2xk9/pdb
DescriptorCHECKPOINT KINASE 2, N-{4-[(1E)-N-(N-hydroxycarbamimidoyl)ethanehydrazonoyl]phenyl}-7-nitro-1H-indole-2-carboxamide (3 entities in total)
Functional Keywordsstructure-based drug design, transferase
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains1
Total formula weight36826.42
Authors
Lountos, G.T.,Jobson, A.G.,Tropea, J.E.,Self, C.,Shoemaker, R.H.,Pommier, Y.,Waugh, D.S. (deposition date: 2010-07-07, release date: 2011-07-20, Last modification date: 2023-12-20)
Primary citationLountos, G.T.,Jobson, A.G.,Tropea, J.E.,Self, C.R.,Zhang, G.,Pommier, Y.,Shoemaker, R.H.,Waugh, D.S.
Structural Characterization of Inhibitor Complexes with Checkpoint Kinase 2 (Chk2), a Drug Target for Cancer Therapy.
J.Struct.Biol., 176:292-, 2011
Cited by
PubMed: 21963792
DOI: 10.1016/J.JSB.2011.09.008
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.35 Å)
Structure validation

217705

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