2XK9

Structural analysis of checkpoint kinase 2 (Chk2) in complex with inhibitor PV1533

2XK9 の概要

• エントリーDOI: 10.2210/pdb2xk9/pdb
• 分子名称: CHECKPOINT KINASE 2, N-{4-[(1E)-N-(N-hydroxycarbamimidoyl)ethanehydrazonoyl]phenyl}-7-nitro-1H-indole-2-carboxamide (3 entities in total)
• 機能のキーワード: structure-based drug design, transferase
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36826.42

構造登録者

Lountos, G.T.,Jobson, A.G.,Tropea, J.E.,Self, C.,Shoemaker, R.H.,Pommier, Y.,Waugh, D.S. (登録日: 2010-07-07, 公開日: 2011-07-20, 最終更新日: 2023-12-20)

• 主引用文献: Lountos, G.T.,Jobson, A.G.,Tropea, J.E.,Self, C.R.,Zhang, G.,Pommier, Y.,Shoemaker, R.H.,Waugh, D.S.; Structural Characterization of Inhibitor Complexes with Checkpoint Kinase 2 (Chk2), a Drug Target for Cancer Therapy.; J.Struct.Biol., 176:292-, 2011; PubMed: 21963792; DOI: 10.1016/J.JSB.2011.09.008

実験手法

X-RAY DIFFRACTION (2.35 Å)