2XG4

E. coli P pilus chaperone-subunit complex PapD-PapH bound to pilus biogenesis inhibitor, pilicide 2c

Summary for 2XG4

Entry DOI	10.2210/pdb2xg4/pdb
Related	1N0L 1PDK 1QPP 1QPX 2J2Z 2WMP 2XG5 3DPA
Descriptor	CHAPERONE PROTEIN PAPD, PAP FIMBRIAL MINOR PILIN PROTEIN, (3R)-8-CYCLOPROPYL-6-(MORPHOLIN-4-YLMETHYL)-7-(1-NAPHTHYLMETHYL)-5-OXO-2,3-DIHYDRO-5H-[1,3]THIAZOLO[3,2-A]PYRIDINE-3-CARBOXYLIC ACID, ... (6 entities in total)
Functional Keywords	chaperone, chaperone-surface active protein complex
Biological source	ESCHERICHIA COLI More
Cellular location	Periplasm: P15319 Secreted: P07111
Total number of polymer chains	2
Total formula weight	44515.22
Authors	Remaut, H.,Phan, G.,Buelens, F.,Chorell, E.,Pinkner, J.S.,Edvinsson, S.,Almqvist, F.,Hultgren, S.J.,Waksman, G. (deposition date: 2010-05-30, release date: 2010-07-14, Last modification date: 2023-12-20)
Primary citation	Chorell, E.,Pinkner, J.S.,Phan, G.,Edvinsson, S.,Buelens, F.,Remaut, H.,Waksman, G.,Hultgren, S.J.,Almqvist, F. Design and Synthesis of C-2 Substituted Thiazolo and Dihydrothiazolo Ring-Fused 2-Pyridones: Pilicides with Increased Antivirulence Activity. J.Med.Chem., 53:5690-, 2010 Cited by PubMed: 20586493 DOI: 10.1021/JM100470T PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation