2XG4

E. coli P pilus chaperone-subunit complex PapD-PapH bound to pilus biogenesis inhibitor, pilicide 2c

2XG4 の概要

• エントリーDOI: 10.2210/pdb2xg4/pdb
• 関連するPDBエントリー: 1N0L 1PDK 1QPP 1QPX 2J2Z 2WMP 2XG5 3DPA
• 分子名称: CHAPERONE PROTEIN PAPD, PAP FIMBRIAL MINOR PILIN PROTEIN, (3R)-8-CYCLOPROPYL-6-(MORPHOLIN-4-YLMETHYL)-7-(1-NAPHTHYLMETHYL)-5-OXO-2,3-DIHYDRO-5H-[1,3]THIAZOLO[3,2-A]PYRIDINE-3-CARBOXYLIC ACID, ... (6 entities in total)
• 機能のキーワード: chaperone, chaperone-surface active protein complex
• 由来する生物種: ESCHERICHIA COLI; 詳細
• 細胞内の位置: Periplasm: P15319; Secreted: P07111
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 44515.22

構造登録者

Remaut, H.,Phan, G.,Buelens, F.,Chorell, E.,Pinkner, J.S.,Edvinsson, S.,Almqvist, F.,Hultgren, S.J.,Waksman, G. (登録日: 2010-05-30, 公開日: 2010-07-14, 最終更新日: 2023-12-20)

• 主引用文献: Chorell, E.,Pinkner, J.S.,Phan, G.,Edvinsson, S.,Buelens, F.,Remaut, H.,Waksman, G.,Hultgren, S.J.,Almqvist, F.; Design and Synthesis of C-2 Substituted Thiazolo and Dihydrothiazolo Ring-Fused 2-Pyridones: Pilicides with Increased Antivirulence Activity.; J.Med.Chem., 53:5690-, 2010; PubMed: 20586493; DOI: 10.1021/JM100470T

実験手法

X-RAY DIFFRACTION (2.4 Å)