2XEM

Induced-fit and allosteric effects upon polyene binding revealed by crystal structures of the Dynemicin thioesterase

Summary for 2XEM

Entry DOI	10.2210/pdb2xem/pdb
Related	2XFL
Descriptor	DYNE7, (3E,5E,7E,9E,11E,13E)-pentadeca-3,5,7,9,11,13-hexaen-2-one (3 entities in total)
Functional Keywords	biosynthetic protein, polyketide biosynthesis, enediyne antitumor agent, thioesterase
Biological source	MICROMONOSPORA CHERSINA
Total number of polymer chains	4
Total formula weight	67963.23
Authors	Liew, C.W.,Sharff, A.,Kotaka, M.,Kong, R.,Bricogne, G.,Liang, Z.X.,Lescar, J. (deposition date: 2010-05-17, release date: 2010-10-13, Last modification date: 2023-12-20)
Primary citation	Liew, C.W.,Sharff, A.,Kotaka, M.,Kong, R.,Sun, H.,Qureshi, I.,Bricogne, G.,Liang, Z.X.,Lescar, J. Induced-Fit Upon Ligand Binding Revealed by Crystal Structures of the Hot-Dog Fold Thioesterase in Dynemicin Biosynthesis. J.Mol.Biol., 404:291-, 2010 Cited by PubMed: 20888341 DOI: 10.1016/J.JMB.2010.09.041 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation