2XDA

STRUCTURE OF HELICOBACTER PYLORI TYPE II DEHYDROQUINASE IN COMPLEX WITH INHIBITOR COMPOUND (4R,6R,7S)-2-(2-Cyclopropyl)ethyl-4,6,7- trihydroxy-4,5,6,7-tetrahydrobenzo(b)thiophene-4-carboxylic acid

2XDA の概要

• エントリーDOI: 10.2210/pdb2xda/pdb
• 関連するPDBエントリー: 1J2Y 2C4V 2C4W 2C57 2WKS 2XB9 2XD9
• 分子名称: 3-DEHYDROQUINATE DEHYDRATASE, (4R,6R,7S)-2-(2-CYCLOPROPYLETHYL)-4,6,7-TRIHYDROXY-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-4-CARBOXYLIC ACID (3 entities in total)
• 機能のキーワード: aromatic amino acid biosynthesis, lyase
• 由来する生物種: HELICOBACTER PYLORI
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18797.60

構造登録者

Paz, S.,Tizon, L.,Otero, J.M.,Llamas-Saiz, A.L.,Fox, G.C.,van Raaij, M.J.,Lamb, H.,Hawkins, A.R.,Castedo, L.,Gonzalez-Bello, C. (登録日: 2010-04-30, 公開日: 2010-11-24, 最終更新日: 2023-12-20)

• 主引用文献: Paz, S.,Tizon, L.,Otero, J.M.,Llamas-Saiz, A.L.,Fox, G.C.,van Raaij, M.J.,Lamb, H.,Hawkins, A.R.,Lapthorn, A.J.,Castedo, L.,Gonzalez-Bello, C.; Tetrahydrobenzothiophene derivatives: conformationally restricted inhibitors of type II dehydroquinase.; ChemMedChem, 6:266-272, 2011; PubMed: 21275050; DOI: 10.1002/cmdc.201000343

実験手法

X-RAY DIFFRACTION (1.85 Å)