2XCF

Crystal structure of HCV NS3 protease with a boronate inhibitor

2XCF の概要

• エントリーDOI: 10.2210/pdb2xcf/pdb
• 分子名称: NS3 PROTEASE, NS4A, ZINC ION, ... (6 entities in total)
• 機能のキーワード: protease, boronate inhibitor, viral reproduction, hydrolase
• 由来する生物種: HEPATITIS C VIRUS; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 47604.93

構造登録者

Li, X.,Zhang, Y.-K.,Liu, Y.,Ding, C.Z.,Li, Q.,Zhou, Y.,Plattner, J.J.,Baker, S.J.,Qian, X.,Fan, D.,Liao, L.,Ni, Z.-J.,White, G.V.,Mordaunt, J.E.,Lazarides, L.X.,Slater, M.J.,Jarvest, R.L.,Thommes, P.,Ellis, M.,Edge, C.M.,Hubbard, J.A.,Nassau, P.,McDowell, B.,Skarzynski, T.J.,Rowland, P.,Somers, D.O.,Kazmierski, W.M.,Grimes, R.M.,Wright, L.L.,Smith, G.K.,Zou, W.,Wright, J.,Pennicott, L.E. (登録日: 2010-04-22, 公開日: 2010-06-02, 最終更新日: 2019-02-06)

• 主引用文献: Li, X.,Zhang, Y.-K.,Liu, Y.,Ding, C.Z.,Li, Q.,Zhou, Y.,Plattner, J.J.,Baker, S.J.,Qian, X.,Fan, D.,Liao, L.,Ni, Z.-J.,White, G.V.,Mordaunt, J.E.,Lazarides, L.X.,Slater, M.J.,Jarvest, R.L.,Edge, C.M.,Hubbard, J.A.,Nassau, P.,Mcdowell, B.,Skarzynski, T.J.,Thommes, P.,Ellis, M.,Rowland, P.,Somers, D.O.,Kazmierski, W.M.,Grimes, R.M.,Wright, L.L.,Smith, G.K.,Zou, W.,Wright, J.,Pennicott, L.E.; Synthesis and Evaluation of Novel Alpha-Amino Cyclic Boronates as Inhibitors of Hcv Ns3 Protease.; Bioorg.Med.Chem.Lett., 20:3550-, 2010; PubMed: 20493689; DOI: 10.1016/J.BMCL.2010.04.129

実験手法

X-RAY DIFFRACTION (2.48 Å)