2XAA

Alcohol dehydrogenase ADH-'A' from Rhodococcus ruber DSM 44541 at pH 8.5 in complex with NAD and butane-1,4-diol

Summary for 2XAA

Entry DOI	10.2210/pdb2xaa/pdb
Descriptor	SECONDARY ALCOHOL DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ZINC ION, ... (5 entities in total)
Functional Keywords	carbonyl reductase, ketoreductase, oxidoreductase
Biological source	RHODOCOCCUS RUBER
Total number of polymer chains	4
Total formula weight	144331.79
Authors	Kroutil, W.,Gruber, K.,Grogan, G. (deposition date: 2010-03-30, release date: 2010-08-11, Last modification date: 2023-12-20)
Primary citation	Karabec, M.,Lyskowski, A.,Tauber, K.C.,Steinkellner, G.,Kroutil, W.,Grogan, G.,Gruber, K. Structural Insights Into Substrate Specificity and Solvent Tolerance in Alcohol Dehydrogenase Adh-'A' from Rhodococcus Ruber Dsm 44541. Chem.Commun.(Camb.), 46:6314-, 2010 Cited by PubMed Abstract: The structure of the alcohol dehydrogenase ADH-'A' from Rhodococcus ruber reveals possible reasons for its remarkable tolerance to organic co-solvents and suggests new directions for structure-informed mutagenesis to produce enzymes of altered substrate specificity or improved selectivity. PubMed: 20676439 DOI: 10.1039/C0CC00929F PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation