2XAA

Alcohol dehydrogenase ADH-'A' from Rhodococcus ruber DSM 44541 at pH 8.5 in complex with NAD and butane-1,4-diol

2XAA の概要

• エントリーDOI: 10.2210/pdb2xaa/pdb
• 分子名称: SECONDARY ALCOHOL DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ZINC ION, ... (5 entities in total)
• 機能のキーワード: carbonyl reductase, ketoreductase, oxidoreductase
• 由来する生物種: RHODOCOCCUS RUBER
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 144331.79

構造登録者

Kroutil, W.,Gruber, K.,Grogan, G. (登録日: 2010-03-30, 公開日: 2010-08-11, 最終更新日: 2023-12-20)

主引用文献

Karabec, M.,Lyskowski, A.,Tauber, K.C.,Steinkellner, G.,Kroutil, W.,Grogan, G.,Gruber, K.
Structural Insights Into Substrate Specificity and Solvent Tolerance in Alcohol Dehydrogenase Adh-'A' from Rhodococcus Ruber Dsm 44541.
Chem.Commun.(Camb.), 46:6314-, 2010

PubMed Abstract: The structure of the alcohol dehydrogenase ADH-'A' from Rhodococcus ruber reveals possible reasons for its remarkable tolerance to organic co-solvents and suggests new directions for structure-informed mutagenesis to produce enzymes of altered substrate specificity or improved selectivity.

PubMed: 20676439
DOI: 10.1039/C0CC00929F

実験手法

X-RAY DIFFRACTION (2.8 Å)