2X8P

Crystal Structure of CbpF in Complex with Atropine by Co- Crystallization

2X8P の概要

• エントリーDOI: 10.2210/pdb2x8p/pdb
• 関連するPDBエントリー: 2V04 2V05 2VYU 2X8M 2X8O
• 分子名称: CHOLINE-BINDING PROTEIN F, SULFATE ION, (1R,5S)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL (2R)-3-HYDROXY-2-PHENYLPROPANOATE, ... (6 entities in total)
• 機能のキーワード: choline-binding protein, lipid-binding-protein
• 由来する生物種: STREPTOCOCCUS PNEUMONIAE
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37702.78

構造登録者

Silva-Martin, N.,Hermoso, J.A. (登録日: 2010-03-10, 公開日: 2011-04-06, 最終更新日: 2023-12-20)

主引用文献

Silva-Martin, N.,Retamosa, M.G.,Maestro, B.,Bartual, S.G.,Rodes, M.J.,Garcia, P.,Sanz, J.M.,Hermoso, J.A.
Crystal Structures of Cbpf Complexed with Atropine and Ipratropium Reveal Clues for the Design of Novel Antimicrobials Against Streptococcus Pneumoniae.
Biochim.Biophys.Acta, 1840:129-, 2013

PubMed Abstract: Streptococcus pneumoniae is a major pathogen responsible of important diseases worldwide such as pneumonia and meningitis. An increasing resistance level hampers the use of currently available antibiotics to treat pneumococcal diseases. Consequently, it is desirable to find new targets for the development of novel antimicrobial drugs to treat pneumococcal infections. Surface choline-binding proteins (CBPs) are essential in bacterial physiology and infectivity. In this sense, esters of bicyclic amines (EBAs) such as atropine and ipratropium have been previously described to act as choline analogs and effectively compete with teichoic acids on binding to CBPs, consequently preventing in vitro pneumococcal growth, altering cell morphology and reducing cell viability.

PubMed: 24036328
DOI: 10.1016/J.BBAGEN.2013.09.006

実験手法

X-RAY DIFFRACTION (2.27 Å)