2X74

Human foamy virus integrase - catalytic core.

2X74 の概要

• エントリーDOI: 10.2210/pdb2x74/pdb
• 関連するPDBエントリー: 2X6N 2X6S 2X78
• 分子名称: INTEGRASE (2 entities in total)
• 機能のキーワード: viral protein, retroviral integrase, dna-directed dna polymerase, nucleotidyltransferase, dna integration, aspartyl protease, dna recombination, transferase, nuclease, hydrolase
• 由来する生物種: HUMAN SPUMARETROVIRUS
• 細胞内の位置: Integrase: Virion (Potential). Protease/Reverse transcriptase/ribonuclease H: Host nucleus (By similarity): P14350
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 136592.27

構造登録者

Rety, S.,Delelis, O.,Rezabkova, L.,Dubanchet, B.,Legrand, P.,Silhan, J.,Lewit-Bentley, A. (登録日: 2010-02-23, 公開日: 2010-08-11, 最終更新日: 2024-11-13)

主引用文献

Rety, S.,Rezabkova, L.,Dubanchet, B.,Silhan, J.,Legrand, P.,Lewit-Bentley, A.
Structural Studies of the Catalytic Core of the Primate Foamy Virus (Pfv-1) Integrase
Acta Crystallogr.,Sect.F, 66:881-, 2010

PubMed Abstract: Retroviral integrases are vital enzymes in the viral life cycle and thus are important targets for antiretroviral drugs. The structure of the catalytic core domain of the integrase from human foamy virus, which is related to HIV-1, has been solved. The structure of the protein is presented in two different crystal forms, each containing several molecules in the asymmetric unit, with and without the essential manganese or magnesium ion, and the structures are compared in detail. This allows regions of high structural variability to be pinpointed, as well as the effect of divalent cations on the conformation of the catalytic site.

PubMed: 20693659
DOI: 10.1107/S1744309110022852

実験手法

X-RAY DIFFRACTION (2.34 Å)