2X4A

Crystal structure of the C-terminal domain of InvA

2X4A の概要

• エントリーDOI: 10.2210/pdb2x4a/pdb
• 関連するPDBエントリー: 2X49
• 分子名称: INVASION PROTEIN INVA, 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, PHOSPHATE ION, ... (4 entities in total)
• 機能のキーワード: protein transport, transport, pathogenesis
• 由来する生物種: SALMONELLA ENTERICA SUBSP. ENTERICA SEROVAR TYPHIMURIUM
• 細胞内の位置: Cell inner membrane; Multi-pass membrane protein (Potential): P0A1I3
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38564.29

構造登録者

Worrall, L.J.,Vuckovic, M.,Strynadka, N.C.J. (登録日: 2010-01-28, 公開日: 2010-05-05, 最終更新日: 2023-12-20)

主引用文献

Worrall, L.J.,Vuckovic, M.,Strynadka, N.C.J.
Crystal Structure of the C-Terminal Domain of the Salmonella Type III Secretion System Export Apparatus Protein Inva.
Protein Sci., 19:1091-, 2010

PubMed Abstract: InvA is a prominent inner-membrane component of the Salmonella type III secretion system (T3SS) apparatus, which is responsible for regulating virulence protein export in pathogenic bacteria. InvA is made up of an N-terminal integral membrane domain and a C-terminal cytoplasmic domain that is proposed to form part of a docking platform for the soluble export apparatus proteins notably the T3SS ATPase InvC. Here, we report the novel crystal structure of the C-terminal domain of Salmonella InvA which shows a compact structure composed of four subdomains. The overall structure is unique although the first and second subdomains exhibit structural similarity to the peripheral stalk of the A/V-type ATPase and a ring building motif found in other T3SS proteins respectively.

PubMed: 20306492
DOI: 10.1002/PRO.382

実験手法

X-RAY DIFFRACTION (2.54 Å)